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mDIXON Quant fat fraction study of liver steatosis

Case Study
Pedersen, Erik, PhD, DMSc Aarhus University Hospital, Dept. Radiology • Denmark

Patient history

Previous MR in this patient has shown a large liver with fatty spots and signs of general steatosis.
The patient was now imaged for fat fraction mapping using mDIXON Quant at Aarhus University Hosptal.

MR examination

Fat fraction mapping was done using Ingenia 1.5T with mDIXON Quant.
With mDIXON Quant, a full 3D acquisition is achieved in one breath hold. The results are immediately reconstructed on the scanner and allow to work with them right away, without time-consuming post-processing.

Images

Click on an image to enlarge.
Fat fraction color map mDIXON Quant<br><br>
Fat fraction color map
mDIXON Quant

Fat fraction % mDIXON Quant, high resolution<br>
Voxels 2 x 2 x 2 mm  <br> 
Breath hold time 19 sec.  <br>Fat fraction % mDIXON Quant, low resolution<br>
Voxels 3 x 3 x 3 mm  <br> 
Breath hold time 11 sec. <br>
Fat fraction %
Fat fraction %
mDIXON Quant, high resolution
Voxels 2 x 2 x 2 mm
Breath hold time 19 sec.
mDIXON Quant, low resolution
Voxels 3 x 3 x 3 mm
Breath hold time 11 sec.
T2W Sames slice as same slice as mDIXON QuantT2* map mDIXON Quant<br>
T2W
T2* map
Sames slice as same slice as mDIXON Quant
mDIXON Quant

 
   

An average fat fraction of 16% and peak fat fraction of approximately 22% is found.
Click on the mDIXON Quant the images to enlarge, then click again to zoom and see the ROIs of 12% and 20% fat fraction.

Diagnosis

Steatosis hepatis magno gradu and focal/segmental steatosis.

Clinical impact

mDIXON Quant provides a quantitative estimation of the fat fraction in the liver. This allows us to look at specific portions of the liver that might be diseased.

It used to be a very tedious task to quantify anything in the liver. Now, with mDIXON Quant, a full 3D acquisition is achieved in one breath hold. The results are immediately reconstructed on the scanner and allow to work with them right away, without time-consuming post-processing.

For patients with known fatty livers who need to be followed over time, mDIXON Quant opens a window, allowing to follow the status of the liver over time without needle biopsies. 

  

Related reading:



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Jul 18, 2014

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Case Study
Ingenia 1.5T
Body, dStream, fat fraction, Liver, mDIXON Quant, steatosis, T2 star
 

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