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ISMRM 2012 presentations by Ingenia users

Clinical News
MRI NetForum Team Philips Healthcare • Netherlands

At the 20th Scientific Meeting of the ISMRM, held in Melbourne, May 5-11, a number of presentations are given by users of an Ingenia system with dStream architecture.

Dual Breath-Hold 3D Whole Heart Cine Cardiac MRI: Feasibility and Initial Experience

Marijn van Stralen1, Jesse Habets2, Mieke M.P. Driessen3,4, Hamza El Aïdi2,3, Josien P.W. Pluim1, Tim Leiner2
1Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 2Radiology, University Medical Center Utrecht, Utrecht, Netherlands; 3Cardiology, University Medical Center Utrecht, Utrecht, Netherlands; 4The interuniversity cardiology institute of the Netherlands, Utrecht, Netherlands

We demonstrate the feasibility of dual breath-hold whole heart 3D cine bSSFP cardiac MR with retrospective reconstruction of any desired viewing plane. The proposed method allowed fast and accurate assessment of global LV functional parameters in comparison with standard 2D bSSFP cine imaging acquired in dedicated predefined cardiac axis orientations. This method saves costly scan time by eliminating planning and reducing acquisition time and may be of value in subjects that are unable to undergo a complete cardiac evaluation with conventional 2D cine bSSFP methods.

Computer Poster, abstract number 3843


Echo Time Compensation Adds Robustness to Symmetrically Sampled Two Point Dixon Imaging

Thobias Romu1, 2, Louise Elander3, Magnus Borga1, 2, Olof Dahlqvist Leinhard, 24
1Department of Biomedical Engineering, Linköpings Universitet, Linköping, Ostergotland, Sweden;
2CMIV, Linköpings Universitet, Linköping, Sweden; 3County Council of Ostergotland, Linköping, Sweden; 4Depts of Radiation Physics, Linköping University and Radiation Physics, UHL County Council of Ostergotland, Linköping, Sweden

When leaving the comfortable zone of the first OP/IP echo’s small adjustments in TE can make a huge difference for symmetrically sampled Dixon imaging. Fortunately on the fly compensation is relatively easy using a short single voxel spectroscopy scan and a model of the fat/water interference. The method is tested using the second OP and third IP echo, both in vitro and in vivo.

Computer Poster, abstract number 1364


Free-Breathing First-Pass 3D Perfusion Imaging of the Heart

Johannes F.M. Schmidt1, Lukas Wissmann1, Robert Manka1, 2, Peter Boesiger1, Sebastian Kozerke1
1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland;
2Department of Cardiology, University Hospital Zurich, Zurich, Switzerland


Scan acceleration methods have proven invaluable for dynamic contrast-enhanced perfusion imaging. One practical issue, however, relates to the requirement of breathholding or shallow breathing which cannot always be ensured in clinical routine exams. An extended k-t PCA algorithm is proposed which corrects for non-rigid frame-to-frame motion based on motion operators derived from two pencil-beam navigators for feet-head and anterior-posterior
motion detection and the fully sampled k-t training data. It is demonstrated that this
approach successfully corrects for respiratory motion artifacts and hence enables free-
breathing 3D cardiac perfusion MRI. 
This study involves use of Ingenia with software that is not available for sale.

Computer Poster, abstract number 3893


Improved Reconstruction of Partial Fourier 3D Dual-Echo Dixon Images

Gregory J. Wilson1, 2, Anne-Sophie Glantenay3, Holger Eggers4, Gwenael Herigault3, Thomas G. Perkins1, John Penatzer1, Jeffrey H. Maki2
1Philips Healthcare, Cleveland, OH, United States; 2Radiology, University of Washington, Seattle, WA, United States; 3Philips Healthcare, Best, Netherlands; 4Philips Research, Hamburg, Germany

Calculated in-phase and opposed-phase images can be produced from dual-echo Dixon imaging with flexible echo times. Potentially, this sequence could replace the standard in-phase and opposed-phase multi-slice FFE scan in a liver exam, shortening exam times. For adequate resolution, however, the 3D dual-echo Dixon scan must be acquired with partial Fourier during a breathhold. Partial Fourier acquisitions complicate Dixon reconstruction as phase information is compromised. This study evaluates a new partial Fourier reconstruction method that is compatible with analytical Dixon water-fat separation.

Computer Poster, abstract number 4011


An Integrated Pencil-Beam Probe for Assessing the Arterial Input Function in Quantitative 3D Myocardial Perfusion Imaging

Lukas Wissmann1, Johannes F.M. Schmidt1, Robert Manka1, 2, Sebastian Kozerke1
1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland;
2Department of Cardiology, University Hospital Zurich, Zurich, Switzerland

The tracer dose in dynamic contrast-enhanced magnetic resonance imaging is crucial for myocardial perfusion quantification. Higher dose is beneficial for myocardial signal-to-noise ratio, but increases the risk of left-ventricular signal saturation in the image due to shorter T1. This study introduces a new acquisition method for the arterial input function using a pencil-beam probe. It is demonstrated that signal saturation in the probe can be avoided by reducing the delay after the saturation pulse. Perfusion quantification from 3D perfusion imaging with the pencil beam probe versus image based assessment of the arterial input function at half and full dose is shown.
This study involves use of Ingenia with software that is not available for sale.

Computer Poster, abstract number 0089


Introducing Dynamic Multi-Exponential T2-Relaxation for Studying Muscle Pattern & Activation in the Human

Burkhard Mädler1, Jürgen Gieseke2, 3, Volker A. Coenen1
1Neurosurgery and Stereotaxis, University Bonn, Bonn, NRW, Germany; 2Philips Healthcare, Best, Netherlands; 3Radiology, University Bonn, Bonn, NRW, Germany

We successfully demonstrate the ability of acquiring high resolution in-vivo T2-relaxation data for quantitative multi-component analysis in human muscle with adequate B1-correction techniques. The T2-components identified are in agreement with recent non-spatially resolved studies from high SNR single voxel T2-experiment. The ability to monitor dynamic changes in muscle-compartmentalization might provide a powerful technique to assess the effectiveness of specific exercise and rehabilitation protocols and monitor treatment efficacy of interventions. This information may proof very valuable to understand compensatory muscle activation in the healthy human subjects as well as patterns associated with injury and/or pathophysiology.

Computer Poster, abstract number 0047


Minimal Artifact Factor SENSE

Johannes M. Peeters1, Miha Fuderer1
1Philips Healthcare, Best, Netherlands

In this work, an extension of the SENSE parallel imaging framework is proposed. In this new framework called Minimal Artifact Factor SENSE (MAF-SENSE), also artifact probability due to incorrect knowledge of the receiver coil sensitivities is taken into account. The latter is realized by adding an uncertainty in this knowledge in order to enable weighting of residual artifact level and SNR in the inversion problem. Results show that MAF-SENSE is well capable of removing residual aliasing artifacts caused by usage of incorrect receiver coil sensitivities.

Computer Poster, abstract number 3353


MR Imaging Improves Endoleak Detection in Patients After Endovascular Abdominal Aneurysm Repair

Jesse Habets1, Herman J.A. Zandvoort2, Sandra A. Cornelissen1, 3, Frans L. Moll2, L. Wilbert Bartels3, Joost A. van Herwaarden2, Tim Leiner1
1Radiology, University Medical Center Utrecht, Utrecht, Netherlands; 2Vascular Surgery, University Medical Center Utrecht, Utrecht, Netherlands; 3Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands

Endovascular repair for abdominal aortic aneurysm (EVAR) requires life-long postoperative imaging follow-up to detect complications. Prior work has shown that MRI with a blood pool agent with 85% albumin binding is more sensitive than CTA for endoleak detection, especially for slow flow and type II endoleaks. This work found that a gadolinium contrast agent with just 5% albumin binding is highly sensitive for the detection of endoleaks in patients with AAA growth and no or uncertain endoleak on CT angiography.
This study involves use of Ingenia with software that is not available for sale.

Computer Poster, abstract number 1201


Pitfalls of Using T2-Weighted Imaging for Visualizing Myocardial Edema Using CMR

Ramkumar Krishnamurthy1, Amol Pednekar2, Benjamin Cheong3, Claudio Arena3, Raja Muthupillai3
1BioEngineering, Rice University, Houston, TX, United States; 2Philips HealthCare; 3Radiology, St. Luke's Episcopal Hospital, Houston, TX, United States

In this animal study, we study the effect of different T2 weighting on determination of the area at risk (AAR) in cardiac black-blood T2 weighted images. After LAD occlusion in five pigs, black blood images of short axis at different T2 weightings were obtained and AAR were determined as regions with signal intensity greater than ‘mean + 2,3 and 4 SD ‘ of remote myocardium. Significant differences in AAR were observed with different quantifying metrics as well as T2 weighting. A significant overlap of absolute T2 values were also observed.

Computer Poster, abstract number 3953


Single-Echo Dixon Imaging for First-Pass Contrast-Enhanced Peripheral Angiography Without Subtraction

Holger Eggers1, Liesbeth Geerts-Ossevoort2, Evert-Jan Vonken3, Tim Leiner3
1Philips Research, Hamburg, Germany; 2Philips Healthcare, Best, Netherlands; 3University Medical Center Utrecht, Utrecht, Netherlands

A flexible dual-echo Dixon method was recently demonstrated to permit first-past contrast-enhanced peripheral angiography without subtraction. In this work, the feasibility of replacing it by a single-echo Dixon method is studied. Fat-suppressed images were reconstructed from dual-echo acquisitions in patients, once separately from the first and the second echo with a single-echo Dixon method and once from both echoes with a dual-echo Dixon method. While single-echo acquisitions promise to decrease scan time or increase spatial resolution, they prove to be more prone to flow and swapping artifacts and more sensitive to the choice of echo time(s).

Computer Poster, abstract number 1199


Subtractionless First-Pass Single-Dose Peripheral MRA Using Two-Point Dixon Fat-Saturation

Tim Leiner1, Bastiaan Versluis2, Liesbeth Geerts3, Eveline Alberts3, Jeroen Hendrikse4, Evert Jan Vonken4, Holger Eggers5
1Department of Radiology , Utrecht University Medical Center, Utrecht, Netherlands; 2Department of Radiology, Maastricht University Medical Center, Maastricht, Netherlands; 3Clinical Science Department, Philips Healthcare, Best, Netherlands; 4Department of Radiology, Utrecht University Medical Center, Utrecht, Netherlands; 5Sector Imaging Systems, Philips Research, Hamburg, Germany

The feasibility of single contrast medium dose (0.1 mmol/kg) subtractionless dual-echo Dixon imaging for first-pass contrast-enhanced fat-suppressed peripheral MRA is demonstrated in 17 patients with suspected peripheral arterial disease. Vessel to background contrast was uniformly better when compared to conventional subtraction based approaches. Despite the requirement to measure two echoes per TR the proposed method is compatible with high-spatial resolution acquisitions during initial arterial passage of contrast material due to high parallel imaging factors. Dual-echo Dixon peripheral MRA represents substantial timesavings over the conventional subtraction-based approach to peripheral MRA and avoids potential subtraction misregistration artifacts.

Computer Poster, abstract number 0525


Whole-Body DWI: Reduction of Scan Time Using Direct Coronal Acquisition

Hayato Takano1, Tomohiko Horie1, Isao Muro1, Nao Kajihara1, Yutaka Imai1, Makoto Obara2, Tetsuo Ogino2, Akira Suwa2, Marc van Cauteren2, Gwenael Herigault2, Thomas Kwee3, and Taro Takahara4
1Radiology, Tokai University School of Medicine, Isehara, Kanagawa, Japan; 2Philips Healthcare; 3University Medical Center Utrecht; 4Tokai University School of Engineering, Hiratsuka, Kanagawa, Japan

Computer Poster, abstract number 4116



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