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Effect of sarpogrelate on characteristics of coronary artery disease in patients with type 2 diabetes

Publication
Philips CT Clinical Science Philips Healthcare • USA

Lee DH, Chun EJ, Hur JH, Min SH, Lee JE, Oh TJ, Kim KM, Jang HC, Han SJ, Kang DK, Kim HJ, Lim S.

 

* This article originally appeared in the February 2017 issue of Atherosclerosis.

Background and Aims

Sarpogrelate, a 5-hydroxytryptamine type 2A antagonist, is a potential antiplatelet agent. We performed a randomized study to evaluate the effect of sarpogrelate on vascular health in Korean patients with diabetes.

 

Methods

Forty diabetic patients aged 58.6 ± 6.8 years with 10-75% coronary artery stenosis, as assessed by coronary computed tomography angiography, were randomly assigned to sarpogrelate 300 mg/day plus aspirin 100 mg/day (SPG + ASA group) or aspirin 100 mg/day alone (ASA group) for 6 months. The primary endpoint of this study was the change in coronary artery disease including the calcium score (CACS), maximal stenosis, and plaque volume (calcified vs. non-calcified). The secondary endpoints were changes in biochemical parameters related to glucose and lipid metabolism, and in subclinical atherosclerosis assessed by ankle-brachial index and pulse wave velocity.

 

Results

After 6-month treatment, there was no significant difference in the changes in CACS, coronary stenosis, ankle-brachial index, and pulse wave velocity, between groups. The total plaque volume decreased from 82.4 ± 14.5 mm3 to 74.6 ± 14.4 mm3 in the SPG + ASA group, but increased from 64.9 ± 16.0 mm3 to 68.6 ± 16.3 mm3 in the ASA group (p < 0.05), mainly driven by changes in the non-calcified component (SPG + ASA group 15.6 ± 4.6 mm3 to 11.2 ± 3.7 mm3 vs. ASA group 21.2 ± 6.2 mm3 to 22.8 ± 6.6 mm3, p < 0.01). Serum C-reactive protein levels and homeostasis model assessment of insulin resistance tended to decrease in the SPG + ASA group, but they were not altered in the ASA group.

 

Conclusions

The present study demonstrated that sarpogrelate treatment may decrease coronary artery plaque volume, particularly the non-calcified portion, in patients with diabetes.

For more information about this publication, check out the PubMed listing for this article.


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Publication
iCT
atherosclerosis, calcium score, Cardiac, Cardiac Viewer, Comprehensive Cardiac Analysis, coronary angiography, coronary arteries, coronary artery disease, diabetes, Extended Brilliance Workspace 4.5, plaque, stenosis, Vascular
 

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