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Image registration and analysis for quantitative myocardial perfusion

Publication
Philips CT Clinical Science Philips Healthcare • USA

Application to dynamic circular cardiac CT

Isola AA, Schmitt H, van Stevendaal U, Begemann PG, Coulon P, Boussel L and Grass M.

* This article originally published in the September 2011 issue of Physics in Medicine and Biology.
Large area detector computed tomography systems with fast rotating gantries enable volumetric dynamic cardiac perfusion studies. Prospectively, ECG-triggered acquisitions limit the data acquisition to a predefined cardiac phase and thereby reduce x-ray dose and limit motion artefacts. Even in the case of highly accurate prospective triggering and stable heart rate, spatial misalignment of the cardiac volumes acquired and reconstructed per cardiac cycle may occur due to small motion pattern variations from cycle to cycle. These misalignments reduce the accuracy of the quantitative analysis of myocardial perfusion parameters on a per voxel basis. An image-based solution to this problem is elastic 3D image registration of dynamic volume sequences with variable contrast, as it is introduced in this contribution. After circular cone-beam CT reconstruction of cardiac volumes covering large areas of the myocardial tissue, the complete series is aligned with respect to a chosen reference volume. The results of the registration process and the perfusion analysis with and without registration are evaluated quantitatively in this paper. The spatial alignment leads to improved quantification of myocardial perfusion for three different pig data sets.
For more information about this publication, check out the PubMed listing for this article.


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Publication
Brilliance 64-channel
3D, Cardiac, Dynamic, ECG-gated dynamic imaging, myocardial perfusion, prospective, quantitative CT
 

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