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Impact of iterative reconstruction on CNR and SNR in dynamic myocardial perfusion imaging in an animal model

Publication
Philips CT Clinical Science Philips Healthcare • USA

Gramer BM, Muenzel D,  Leber V, von Thaden AK, Feussner H, Schneider A, Vembar M, Soni N, Rummeny EJ, and Huber AM.

* This article was originally published online on July 3, 2012 in European Radiology.
Objectives
To evaluate a new iterative reconstruction (IR) algorithm for radiation dose, image quality (IQ), signal-tonoise- ratio (SNR), and contrast-to-noise-ratio (CNR) in multidetector computed tomography (MDCT) dynamic myocardial perfusion imaging (MPI).

Methods
ECG-gated 256-slice MDCT dynamic MPI was performed in six pigs after subtotal balloon occlusion of one artery. Two 100 kVp protocols were compared: high dose (HD): 150 mAs; low dose (LD): 100 mAs. HD images were reconstructed with filtered back projection (FBP), LD images with FBP and different strengths of IR (L1, L4, and L7). IQ (5-point scale), SNR, and CNR (ischemic vs. normal myocardium) values derived from the HD (FBP) images and the different LD images were compared.

Results
Mean SNR values for myocardium were 16.3, 11.3, 13.1, 17.1, and 28.9 for the HD, LD (FBP), LD (L1), LD (L4), and LD (L7) reconstructions, respectively. Mean CNR values were 8.9, 6.3, 7.8, 9.3, and 12.8. IQ was scored as 4.6, 3.3, 4.4, 4.7, and 3.4, respectively. A significant loss of IQ was observed for the LD (L7) images compared to the HD (FBP) images (P<0.05).

Conclusion
Appropriate levels of iterative reconstruction can improve SNR and CNR, facilitating radiation dose savings in CT-MPI without influencing diagnostic quality.
For more information about this publication, check out the PubMed listing for this article.


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Publication
iCT
Cardiac, dose, ECG-gated chest, ECG-gated dynamic imaging, FBP reconstruction, high resolution, image quality, iterative reconstruction, myocardial perfusion
 

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