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Liege hospital studying pCASL for brain perfusion without contrast

Best Practice
Reginster, Pierre, M.D. CHC Saint Joseph Hospital • Belgium
Martin, Bénédicte, M.D. CHC Saint Joseph Hospital • Belgium

Pseudo-Continuous Arterial Spin Labeling (pCASL) is an arterial spin labeling technique showing high SNR and good sensitivity to whole brain perfusion. The pCASL technique combines advantages from continuous ASL and pulsed ASL, such as high SNR and high labeling efficiency.
CHC Saint Joseph Hospital (Liege, Belgium) is using pCASL for high performance brain perfusion imaging without contrast. Benedicte Martin, MD, and Pierre Reginster, MD, demonstrate the strengths of pCASL.
 Pierre Reginster, MD Bénédicte Martin, MD
Pierre Reginster, MD
Bénédicte Martin, MD

Radiologist Pierre Reginster, MD, says:
“pCASL performs as a high SNR method for ASL, with good sensitivity to perfusion. We compared imaging of contrast-enhancing brain tumors with pCASL and DSC (Dynamic Susceptibility Contrast imaging). In 38 exams of 28 patients we found a significant correlation between measured pCASL and DSC signal ratios and between visual scores of enhancement, and significantly lower artifact scores with pCASL than with DSC.”

“pCASL may be a good alternative to DSC and presents two advantages: the absence of injection of a contrast agent, which allows us to increase the frequency of controls in patients with renal failure; and the reduction of artifacts, contributing to good quality exams of some tumors near the skull base.”

“pCASL combines advantages from continuous ASL and pulsed ASL, such as high signal-tonoise ratio and high labeling efficiency. It is implemented with background suppression pulses that help improve signal-to-noise ratio.”
Physicist Bénédicte Martin says: 
“Using the neurovascular 16-channel coil and a 3.0T system, we have evaluated pCASL in about 100 patients that presented with brain tumor or suspicion of brain tumor, and in follow-up after treatment.”

“pCASL is a good alternative for patients with contraindications for contrast media, especially for patients with renal failure.”

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Oct 8, 2013

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Best Practice
Achieva 3.0T, Achieva 3.0T TX, Ingenia 3.0T
Brain, Brain Perfusion, DSC, Neuro, pCASL, Perfusion, T2*

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