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Achieva 3.0T TX fMRI of GBM patient

Case Study
Van Cauter, Sofie, M.D. University Hospitals Leuven • Belgium

Patient history

43 years-old male patient, presented with speech difficulties since three weeks and a tonic-clonic epileptic insult.

The histopathological diagnosis of the lesion was a glioblastoma multiforme.

MR Examination

Due to the location of the tumor 3 fMRI tasks were performed for preoperative risk assesment.

  • Lip movement (block design, start with rest, 10 dynamics rest, 10 dynamics active, block duration 30sec, TR3000)
  • Finger Tapping both hands (block design, start with rest, 10 dynamics rest, 10 dynamics active, block duration 30sec, TR3000)
  • Language Word Generation (Taal1 and Taal2, block design, start with rest, 10 dynamics rest, 10 dynamics active, block duration 30sec, TR3000)

 

In Leuven the language task (Taal) is performed twice as the language activation is expected to be higher in the repeated task.

MR images

 Finger tapping
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Finger tapping

 Language word generation task 1
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Language word generation task 1

 Language word generation task 2
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Language word generation task 2

 Lip movement
<br>
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Lip movement

 fMRI review 2D
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fMRI review 2D

 Motion QC Language
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Motion QC Language

 Smart fusion 3D
Smart fusion 3D

Results

The patient had a complete resection of the lesion. The fMRI results were used in functional neuronavigation, intra-operative cortical mapping was done. This was a high risk operation because of the complete left lateralized language system, located in the vicinity of the lesion and the lip representation in the left primary sensorimotor cortex which was posteriorly and caudally displaced. the patient had no paralysis or dysarthria post-surgery. He was furthermore treated with chemo- and radiotherapy.


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Sep 11, 2012

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Case Study
Achieva 3.0T
32ch SENSE Head coil, eSys, fMRI, Neuro
 

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