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pCASL in child with sickle cell disease

Case Study
Miller, Jeffrey, M.D. Phoenix Children's Hospital • USA

Patient history

An 11-year-old boy with sickle cell disease and chronic left MCA stenosis and arterial insufficiency underwent an MRI exam at Phoenix Children's Hospital (Phoenix, AZ, USA).

MR examination

The exam was performed on an Ingenia 3.0T using a 32-channel dS Head coil. The exam included pCASL and DSC CBF.

pCASL was performed with voxel size 0.9 cm x 1.15 cm x 4 cm, scan time 4:08 min.


Click on an image to enlarge.
 PASL (previous method) pCASL DSC
PASL (previous method)

Comparison demonstrates that pCASL and DSC CBF are equivalent in showing the perfusion deficit anteriorly (yellow arrows) and the mild perfusion deficiency posteriorly (white arrows). However, the older pulsed ASL (PASL) overestimates the extent of perfusion deficiency, see white arrows posteriorly.

Clinical impact of pCASL

pCASL can be used to help delineate the perfusion abnormality.

Related reading:

Results from case studies are not predictive of results in other cases. Results in other cases may vary.

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Jan 13, 2015

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Case Study
Ingenia 3.0T
Brain, dStream, mDIXON TSE, Neuro, Pediatric, sickle cell disease, Vascular

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