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Research: Towards time-resolved non-CE MRA with CINEMA

Clinical News
Nakamura, Masanobu , R.T. Yaesu Clinic • Japan

Non-contrast enhanced imaging has gained momentum over the past years. Newly developed techniques, such as B-TRANCE, have proven useful in the evaluation of several diseases. One aspect that has been lacking though, was the ability to depict hemodynamic processes. Yaesu clinic, Chuo-ku, Tokyo, Japan is using an Achieva 3.0T scanner with special software to perform of non-CE MRA research in this field. The team led by Masanobu Nakamura, radiotechnologist, is exploring time-resolved non-CE MRA in collaboration with Kumamoto University, Kumamoto Central hospital and Juntendo University Hospital.

Time-resolved non-CE MRA with CINEMA

CINEMA stands for Contrast inherent Inflow Enhanced Multi-phase Angiography. In order to depict inflow into the vascular tree, the team has developed an imaging sequence based on a multi-phase ASL approach using the FAIR preparation scheme. In this approach, two acquisitions are performed – one with and one without labeling of the inflowing blood. The two acquisitions are subsequently subtracted, resulting in an image where only the inflowing blood is depicted.


Basic principle of the ASL based CINEMA sequence. Two acquisitions are performed, one with and one without labeling of the blood. Subtraction of the two images results in an image of the inflowing blood.

Time-resolved information is obtained by performing a segmented readout, at multiple time points after the labeling pulse. The temporal resolution can be controlled by changing the duration of the readout segments. Inflow of blood into the region of interest can be followed as long as the label persists.

Time resolved information is obtained from the multi-phasic readout.

TOF (left) and CINEMA-FAIR (right) images acquired from a healthy volunteer. MIP images are shown from representative phases in one subject. Temporal resolution 200 ms, spatial resolution 1x1x1 mm 3, scan time 6:49 min.

Selective labeling for identification of supplying arteries

The CINEMA technique may further be extended by the use of selective labeling slabs. In this way, blood flow from a particular artery can be selectively visualized.

Upper left: TOF image used for planning of the labeling slabs. Upper right: Schematic depiction of the labeling slabs. Lower row: Arterial structures supplied by the right internal carotid artery (Rt-ICA), posterior communicating artery (PCA), and left internal carotid artery (Lt-ICA).

Clinical applications

Information on the hemodynamics of blood flow is crucial in several cerebrovascular diseases, such as arterio-venous malformations (AVM’s) and Moyamoya disease. Therefore, CINEMA might potentially play a role in the diagnosis of these diseases.

Moyamoya disease. CINEMA TOF (left) and CINEMA-FAIR (right) images in a patient with Moyamoya disease. The characteristic ‘puff-of-smoke-like’ arterial structures are well depicted.


1  Wyttenbach et al., Radiology (2007)245;186-195
2. Nakamura et al., Proc. ISMRM (2011), 3345
3. Nakamura et al., Proc. ISMRM (2011), 4036

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May 22, 2012

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Clinical News
Achieva 3.0T
ASL, B-TRANCE, Moyamoya disease, mra, Neuro, non-CE MRA, Non-contrast MRA, Vascular

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