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Additional prognostic value of brachial-ankle pulse wave velocity to coronary CTA in patients with suspected CAD

Publication
Philips CT Clinical Science Philips Healthcare • USA

Hwang IC, Jin KN, Kim HL, Kim YN, Im MS, Lim WH, Seo JB, Kim SH, Zo JH, Kim MA.

* This article originally appeared in the January 2018 issue of Atherosclerosis.
Background and Aims
Increased arterial stiffness is associated with a higher risk of future cardiovascular events. We aimed to investigate whether information about arterial stiffness provides additional prognostic value to coronary computed tomography angiography (CCTA) findings.

Methods
A total of 523 consecutive patients (mean age, 58.0 ± 10.3 years; male, 60.6%) with suspected coronary artery disease (CAD), who underwent CCTA and brachial-ankle pulse wave velocity (baPWV) measurement within a month, were retrospectively analyzed. A composite of cardiovascular death, non-fatal myocardial infarction (MI), coronary revascularization, nonfatal stroke, and hospitalization for cardiovascular causes was assessed.

Results
During a median 43.9 months of follow-up (interquartile range, 11.6-66.9 months), the composite endpoint occurred in 66 patients (three cardiovascular deaths, one non-fatal MI, 35 coronary revascularizations, 16 non-fatal strokes, and 45 hospitalizations for cardiovascular causes). After adjustment for clinical risk factors and CCTA findings, higher baPWV was an independent prognostic factor for the composite endpoint (adjusted hazard ratio, 4.717; 95% confidence interval, 2.675-8.319; p < 0.001). The addition of baPWV to clinical risk factors and CCTA findings significantly improved the prediction of cardiovascular events (global χ2 score, from 132 to 154; p = 0.005).

Conclusions
Arterial stiffness provides additional prognostic information to CCTA findings in patients with suspected CAD. The baPWV can serve as a useful clinical tool for risk stratification in this population.
For more information about this publication, check out the PubMed listing for this article.


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Publication
Brilliance 64-channel, Ingenuity CT
Cardiac, coronary angiography, coronary arteries, coronary artery disease, iDose4, retrospective, stroke, Vascular
 

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