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Admission perfusion CT

Philips CT Clinical Science Philips Healthcare

Prognostic value in patients with severe head trauma

Wintermark M, van Melle G, Schnyder P, Revelly JP, Porchet F, Regli L, Meuli R, Maeder P, Chiolero R.


Department of Diagnostic and Interventional Radiology, Surgical Intensive Care Unit, University Hospital, 1011 Lausanne, Switzerland.


To assess the prognostic value of admission perfusion computed tomography (CT) in patients with severe head trauma.


Materials and Methods
This prospective study included 130 patients with severe trauma, aged 19-86 years, admitted with a Glasgow Coma Scale score of 8 or less. They underwent perfusion CT as part of their admission CT survey. Clinical data, unenhanced cerebral CT findings, and perfusion CT scans were evaluated with respect to the Glasgow Outcome Scale (GOS) score at three months. Perfusion CT features were evaluated in patients with intracranial hypertension, cerebral contusions, and juxtadural hematomas. Ordered logistic regression was used to determine risk factors for an unfavorable GOS score at three months.


Perfusion CT was more sensitive than conventional un-enhanced CT in the detection of cerebral contusions. Perfusion CT featured specific patterns with respect to patient outcome, with normal brain perfusion or hyperemia in patients with favorable outcome, and oligemia in patients with unfavorable outcome. The number of arterial territories with low regional cerebral blood volume at perfusion CT was an independent prognostic factor (P =.008), as were mean arterial pressure at the scene of accident (P =.083), base excess at admission (P =.002), presence of skull fractures (P =.041), and signs of herniation (P =.013) at admission unenhanced cerebral CT. Perfusion CT also showed a range of brain perfusion alterations in patients with juxtadural collections, cerebral edema, or intracranial hypertension.


Perfusion CT in patients with severe head trauma provides independent prognostic information regarding functional outcome.


For more information about this publication, check out the PubMed listing for this article.

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Jul 21, 2005

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brain, Brain Perfusion, Head, head trauma, hypertension, Neuro, prospective, trauma

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