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Brain perfusion in children

Philips CT Clinical Science Philips Healthcare

Evolution with age assessed by quantitative perfusion CT

Wintermark M, Lepori D, Cotting J, Roulet E, van Melle G, Meuli R, Maeder P, Regli L, Verdun FR, Deonna T, Schnyder P, Gudinchet F.


Department of Diagnostic and Interventional Radiology, University Hospital, Lausanne, Switzerland.


The objective of this study was to assess the age-related variations of brain perfusion through quantitative cerebral perfusion computed tomography (CT) results in children without brain abnormality.


Brain perfusion CT examinations were performed in 77 children, aged seven days to 18 years. These patients were admitted at our institution for both non-contrast and contrast-enhanced cerebral CT. Only children whose conventional cerebral CT and clinical/radiologic follow-up, including additional investigations, were normal were taken into account for this study (53 of 77).


The average regional rCBF amounts to 40 (mL/100 g per minute) for the first six months of life, peaks at approximately 130 (mL/100 g per minute) at approximately two to four years of age, and finally stabilizes at approximately 50 (mL/100 g per minute) at approximately seven to eight years of age, with a small increase of rCBF values at approximately 12 years of age. The rCBF in the gray matter averages three times that in the white matter, except for the first six months of life. The global CBF represents 10% to 20% of the global cardiac output for the first six months of life, peaks at approximately 55% by two to four years of age, and finally stabilizes at approximately 15% by seven to eight years of age. Specific age-related evolution patterns were identified in the different anatomic areas of the cerebral parenchyma, which could be related to the development of neuroanatomic structures and to the emergence of corresponding cognitive functions.


Quantitative perfusion CT characterization of brain perfusion shows specific age variations. Brain perfusion of each cortical area evolves according to a specific time course, in close correlation with the psychomotor development.


For more information about this publication, check out the PubMed listing for this article.

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May 12, 2007

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brain, Brain Perfusion, contrast-enhanced, Head, Neuro, non-contrast, Pediatric, pediatric head, quantitative CT, Vascular

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