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Risk factor profiling and study of atherosclerotic coronary and morphology with coronary CTA in coronary artery disease among young Indians

Philips CT Clinical Science Philips Healthcare • USA

Chaudhary R, Chauhan A, Singhal M, Bagga S.


* This article originally appeared in the April 2017 edition of the International Journal of Cardiology.


With a decade earlier manifestation of coronary artery disease (CAD) and paucity of data characterizing coronary plaque with coronary computed tomography angiography (CTA) among CAD patients in India, the study aimed to analyze patient characteristics and coronary plaque burden and morphology in young Indian patients with CAD.



Serial coronary CTA was performed in 96 CAD patients. Among 60 patients ≤ 40 years, risk factor and coronary plaque analysis done using a 256- slice CT in 33 patients with acute coronary syndrome (ACS) was compared with 27 patients with chronic stable angina (CSA). Univariate and multivariate analysis was performed, for factors predicting ACS as an outcome among young CAD patients. In addition, quantitative and morphologic plaque characteristics were compared among those ≤ 40 years and > 40 years.



Among 60 subjects ≤ 40 years of age, 77% had dyslipidemia, 70% high lipoprotein(a), 53.33% elevated hs-CRP and 73.33% raised homocysteine. hs-CRP (9.33 vs. 3.33, p value = 0.01) and serum triglycerides (178.67 vs. 141.42, p value = 0.03) were markedly raised in patients with ACS. Statistically significant number of patients in the ACS group had positive remodelling (ACS, 69.7% vs. CSA, 14.8%; p value < 0.001), low attenuation plaque (ACS, 63.6% vs. CSA, 11.1%; p value < 0.001), spotty calcification (ACS, 36.4% vs. CSA, 3.7%; p = 0.002) and non-calcified plaque (ACS, 69.7% vs. CSA, 11.1%; p < 0.001). On multivariate analysis, only lipoprotein(a) N30 mg/dL and composite vulnerability score maintained a predictive value for ACS in patients ≤ 40 years. Statistically significant number of patients in the younger age group had higher mean total plaque volume (66.17 ± 41.31 mm³ vs. 44.94 ± 49.07 mm³; p = 0.03), remodelling index (1.5 ± 0.27 vs. 1.08 ± 0.38; p = 0.0001). Comparing culprit lesion characteristics of ACS patients in the two age groups, positive remodelling (95.8% vs. 70.5%, p = 0.02), spotty calcification (50% vs. 11.7%, p = 0.01) and non-calcified plaque (95.8% vs. 70.5%, p = 0.02) were significantly more frequent in patients ≤ 40 years.



ACS in young Indians is characterized by a higher prevalence of both conventional and newer risk factors. In addition, culprit lesions in young ACS patients are more frequently characterized by coronary plaques with high risk morphological features. This may have implications in terms of preventive strategies to identify this high-risk group.

For more information about this publication, check out the PubMed listing for this article.

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Aug 14, 2017

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atherosclerosis, calcification, Cardiac, coronary artery disease, iDose4, lesion, plaque, Vascular

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